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AqualiftTM – is the most physiologic and safe among all existing implants, which can be used in any anatomic region. Nowadays AqualiftTM is the most perspective implant which soon can take the leadership and dominate in the medical market.
National Medical Technologies Center and SRMC Medicap are concerned in partnership and promotion of advanced technologies in the world market.
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Stem Cells and Aqualift
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Cellular therapy is a medical treatment by means of transplanting living cells into the human body, which makes it possible to substitute the lost, inactive or defective cells of the patient and to obtain a distinct regenerative effect: to restore functioning of separate organs, tissues, and of the organism as a whole.
The concept of a stem cell itself belongs to the Russian scientist Alexander Maksimov who investigated the processes of hematosis. The term “stem cell” was first used in 1908 at the Congress of hematological society in Berlin. In 1951, Lorenz proved that the allogenic marrow is able to protect animals from death caused by stoppage in hematosis after exposure to high dosage of radiation. In 1960s-1970s, the Soviet scientist A.Ya. Fridenshtein studied and cultivated mesenchymal (stromal) stem cells of the bone marrow. In 1981, Martin Evans was the first to extract undifferentiated pluripotent lines of stem cells from the embryoblast (inner cellular mass) of the mouse blastocyst. In 1998, James A.Thomson and John D. Gearhart (Wisconsin University, USA) isolated 5 lines of embryonic stem cells (ESC) out of refrigerated human blastocysts left unused after super ovulation in receiving the impregnated ovules for pregnancy purpose. The published in the journal “Science” (1999) results of those experiments were acknowledged as the third important event in biological science of the 20th century, after discovery of double spiral DNA and deciphering of the human genome.
The unique property of embryonic stem cells is their totypotence which means the ability to initiate growing of various cell types, as well as of the extraembryonic tissues (placenta, embryonic capsules) and of the embryo itself. This property of the ESC has opened wide prospects for their practical application in biology and medicine. The embryonic stem cell differs from the human grown-up cells in that it can theoretically divide infinitely and, which is important, without forming atypical cells of malignant tumors. Thus, this very important property, actual immortality, of the embryonic stem cells allows us to set the aim of obtaining the invaluable material for prolongation of human life.
Without going into details, here is a brief explanation to non-specialists.
The human organism, as any other multicellular one, develops out of a single cell. All the variety of cells and tissues we consist of is just the progeny of this very cell. Development and growth of the organism takes place by way of multiple division of the cells which results in growth of their number, their differentiation and maturing, in other words, the cells become different and acquire unique properties necessary to perform certain functions depending on the place in the organ or tissue where they locate. The mature cell looses its ability for reproduction, fulfills its function and then dies due to some or other reasons. Then it is replaced by another similar cell to go the same route. This process is named regeneration, and thanks to it we remain the same as we are, irrespective of the death of a huge number of cells of our body. As we grow old, or due to infections, impact of toxins, radiation, traumas, lots of other reasons, the regeneration processes slow down or become distorted, which is manifested as a disease or ageing. One of the main factors causing regeneration to slow down is reduction in the number of the so called stem cells.
The stem cells are the main source from where continual renewal of the body cellular structure is taking place. So, revival of this source can relieve us from a lot of sufferings, as well as it can prolong our life. Currently, there have been developed technologies that allow us to obtain stem cells out of various biological materials and to use them for transplantation. Transplantation of stem cells makes it possible to restore the regeneration processes, hence a lot of pathological processes can be eliminated. During last decades, thanks to development and introduction of the new cellular technologies, it became possible to cure diseases practically incurable before.
According to the source of the donor material, we can differentiate the following techniques: xenotransplantation, when introduced are the cells from a certain kind of animal (i.e. the patient is injected with the cells of a sheep or pig); allotransplantation, when the injected cells are taken from another person; and autotransplantation, when the injected cells are the patient’s own cells preliminary separated from him and undergone special treatment.
The main sources of the ESC for medical purposes are the following: abortive material and the material remaining after artificial impregnation; umbilical blood; bone marrow; and some others. Almost at that very time when the first ESC were extracted, there began arguments whether it was ethical to perform such a research and relative therapy. The main issue for these debates remains whether it is ethical to ruin the human embryo for receiving the ESC, even if it is performed at the earliest period of the embryo development. But it should be mentioned here that the researchers use only the “extra” unnecessary blastocytes remaining unclaimed after artificial impregnation “in vitro” (actually, during extracorporal impregnation there is always created an excess of impregnated ovules). In any case, those extra embryos wouldn’t have a chance for life, and they were not created specially for the research aims. Whereas, when applying the ESC in cellular therapy, doctors can relieve sufferings from a lot of various diseases and can even bring recovery to the people whose illnesses are considered incurable at present.
Similar questions arise also concerning the use of fetal materials remaining after abortions. On the one hand, abortions are not ethical themselves. On the other hand, they are legally permitted and are performed irrespective of the fact whether the abortive fetus tissues could be made use of or not. So the question arises whether it is ethical to deprive patients of helpful curing them through methods of fetal therapy. It is obvious that the tissues and cells of the abortive fetuses must be available for medical purposes, the same as the organs and tissues of those killed in accidents are available for transplantations. Naturally, in both types of transplantations, there should be performed a thorough check-up of the donor’s material for contamination with viruses and bacteria.
The other variant of research that is currently underway – obtaining of endless cellular lines – progeny of the ESC. However, when the stem cells are reproducing themselves outside the living organism there is necessarily taking place the process of genetic mutations within the stem cells, which will be inherited by their daughter cells and accumulated in the following generations. Hence, at present so far, it is not safe to use for medical purposes the preparations of reproduced cellular lines, because their population will necessarily contain the cells with chromosome anomalies.
Now that the legislative regulations of many countries are not in favor of cellular technologies development, the center for research and practical application of the ESC has shifted to China. In 2002, there was created in China the “Jilin University Tong Yuan Biological” Center for research in stem cells and development of cellular technologies. The Ukrainian research medical Center “Medicap”, in cooperation with the above Chinese Center, has worked out new elaborations that further develop new cellular technologies. After launching onto the market the physiological biocompatible filler Aqualift, we have started research in using this material as immunoisolator for stem cells. It would serve as a substrate medium for growing of various cells and tissues. The first positive results have already been achieved in that direction.
Potentially, we can grow a lot of tissues, any human organ actually, out of the cells-predecessors. The problem is how to create the appropriate conditions so that the development of the embryonic stem cells would go in the right direction and the transplanted cells would not become the target of the recipient’s immune system. Since 2003, there have been performed pre-clinical experiments at the laboratory equipment of the “Jilin University Tong Yuan Biological” Center for immunoisolation of the donor stem cells with the aim of their further surgical transplantation.
Positive results have been achieved in clinical application of the new method for curing the following diseases: diseases of the endocrine system, liver diseases, diseases of the central nervous system, diseases of the cardiovascular system, ageing, immunodeficiency conditions, blood diseases, oncological diseases, etc.
Interesting and promising results have been obtained in volumentrical contour plastic surgery of the facial soft tissues when combining application of the gel Aqualift and cellular therapy. A pronounced long-term rejuvenating and sanative effect was observed. Further research in that direction is carried out very intensively at present.
The obtained results have proved to be promising in application of the new technologies elaborated by the “Medicap” Company. Based on the obtained results, and taking into account availability of this trend in medicine, on April 25, 2006, there was launched a first-rate Center for transplantation of Stem Cells, and the relative clinic “GUIGU”, in the city of Chanchun of China. The up-to-date non-commercial clinic “GUIGU” is authorized by the sanitary department and has the area of 57.5 thousand square meters. Its cost is 300 million yuans. The clinic includes the diagnostic center, stem cells transplantation center, center for treatment of cardiovascular diseases, departments of endocrinology, gastroenterology, oncology, surgery, neurology, sanitation and cosmetology. The clinic is equipped with the latest up-to-date diagnostic equipment. The PET-CT unit, for instance, is the most advanced achievement in medicine. It allows performing the earliest diagnostics, hence providing the earliest treatment of the patients. There is also organized a medical group consisting of the invited Chinese and foreign qualified medical specialists.
In our further publications, we are planning to supply our viewers with further detailed information about new practical achievements in this area.
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