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AqualiftTM – is the most physiologic and safe among all existing implants, which can be used in any anatomic region. Nowadays AqualiftTM is the most perspective implant which soon can take the leadership and dominate in the medical market.
National Medical Technologies Center and SRMC Medicap are concerned in partnership and promotion of advanced technologies in the world market.
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AQUALIFT versus COLLAGEN
Plastic surgery innovation.
The main mechanisms of the human skin biological ageing reside in the sphere of structural mechanical and biochemical changes of the intercellular substance within the skin dermal layer. Collagen is the basic albumen of the connective tissue, and it performs various biological functions. With advance in age, change of the collagen fiber structure is responsible for the age-related changes. Along with biological “ageing” of the albumin structures, there also takes place inhibition of synthesis of the glycosamineglycanes, that have unique hydrophilic properties, which process is responsible for reduction of hydrophilic behavior of the intercellular medium and reduction of the tissue inner volume. As a result, the skin loses its volume and elasticity, the skin folders transform into wrinkles and remain permanent. Collagen is the major structural component of the skin dermal layer. When injected into the skin, the heterogeneous collagen undergoes gradual biodegradation. Based on the collagen, there have been created fillers of the soft tissues. They possess high-rate biocompatibility with the human body tissues. Collagen preparations, based on 3.5 - 6.5 % bovine collagen, have taken up leading ranks in the world as to frequency of their application as well as by the number of satisfied patients. However, the animal collagen is a foreign albumen to the human body and has a number of negative properties. That’s why injections of collagen are not carried out in the following cases:
- allergic reaction to the bovine collagen,
- allergic diseases,
- autoimmune diseases.
Injections of the bovine collagen, having the property to smooth down wrinkles, are still considered as the “gold standard” by a number of doctors in the USA. This is a cosmetic procedure number four. In the year of 2000, for instance, there were performed about 600 thousand such procedures in the USA.
Among the materials for injection contour plastic surgery, collagen is the least stable, as the effect from such injections can keep on during the average of 4 to 6 months. Besides, some 3 – 5 % of women develop allergic reaction to collagen.
Collagen, being a fibrillar albumen, is structurally built of three spirals (linear polyamides), each of which is left-hand revolving, and winded on each other to make a right-hand revolving spiral. The collagen aminoacid chains are wrapped upon each other and form a “three-fibrous rope” where separate “fibers” are bound together by a hydrogen bond. A distinctive feature of the hydrogen bond is its relatively low strength, its energy is almost ten times lower compared to covalent chemical bond.
It is common knowledge that most of chemical compounds are not soluble in water. When this rule is violated then most often this is the result of intrusion of the hydrogen bonds. Spatial structure of albumens, and of all the other natural biopolymers, is formed thanks to H-bonds originating due to interaction between carbonyl and amide groups , that arrange the linear polyamide (polypeptide) into a spiral having a three-dimensional spatial configuration (supramolecular structure).
Search for the material having unique hydrophilic properties and advantages of the water-soluble collagen structure, and at the same time void of its antigenic properties, has been the purpose of our elaboration.
As a result of introduction of new original technologies by our specialists, there has been obtained a synthetic polyamide that became the basic substance for production of the Aqualift gel. Influence of the hydrogen bonds upon the structure and properties of polymer molecules is exclusively high. The crystal structure of polyamides is formed by H-bonds originating between carbonyl and amine groups. If between the two carbonyl groups there is an even number of carbon atoms, more precisely – methylene groups CH2 , then the amine and carbonyl groups in the neighboring chains appear to be located so favorably that each of them easily reach the next thus forming the H-bond. Similar interdependence is observed in polyurethanes where formation of crystal regions is taking place thanks to analogous interaction between carbonyl and amine groups.
In just the same way, as it is observed for polyamides and polyurethanes, there takes place junction of the parallel-connected polymer chains in the albumens. Yet, the H-bonds also leave for the albumen molecules another way of arrangement – in a spiral shape. At the same time the spiral coils are fixed by these very hydrogen bonds arising between the carbonyl and amine groups.
The method of obtaining the filler having these unique properties is patented.
The macromolecule of the obtained linear synthetic polyamide creates multiple H-bonds arising between the carbonyl and amine groups which create a new spatial permolecular structure.
- Aqualift is a soft tissues filler. It acts by the principle of creating a
depot of physiological 0.9 % solution of sodium chloride enclosed into a matrix of three-dimensional spatial permolecular structure of synthetic linear polyamide based on multiple H-bonds arising between the carbonyl and amine groups. Availability of a big number of active carboxyl groups impart a positive charge to the polymer molecule thus securing high-rate hydrophilicity and water solubility.
- Aqualift – is the most physiological and safest of all existing implants, since its structure and properties in the best way agree with the inner medium of the organism and with the intercellular substance of the skin dermal layer.
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